A Promising Molecule may reverse Brain Damage

There may now be a new treatment to help patients who have suffered a traumatic brain injury (TBI) or a neurological disorder.

The key to this process is a brain molecule called N-acetylaspartate (NAA), also known as the “Antifreeze” molecule, which acts on proteins that are associated with neurological problems and decline in cognitive ability.

When the brain has suffered an injury or disease, levels of NAA decrease. This lowered concentration of NAA allows amyloid-beta fibrils (ABF) to clump together, forming harmful amyloid plaques.

According to a study* by Perelman School of Medicine at the University of Pennsylvania, the addition of the amino acid NAA after a brain trauma serves as an “anti-freeze”: it pauses the clumping of the amyloid-beta fibrils (ABF).

By restoring NAA to normal levels, it was possible to “block progression of amyloid pathologies.” The study also found that adding NAA may even reverse this clumping process.

These findings have important implications for the future treatment of both brain injuries and neurological disorders

If you are experiencing symptoms of CTS or if you are suffering from any brain or spine related disorder or injury and live in the Columbus, Ohio area, contact us today to schedule your appointment with Dr. Shehadi.

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* Journal of Neurotrauma
J Neurotrauma. 2010 Jan; 27(1): 293–298.
doi: 10.1089/neu.2009.0994
PMCID: PMC2824219
PMID: 19803785
Metabolic Acetate Therapy for the Treatment of Traumatic Brain Injury
Peethambaran Arun,1 Prasanth S. Ariyannur, John R. Moffett,1 Guoqiang Xing, Kristen Hamilton, Neil E. Grunberg, John A. Ives, and Aryan M.A. Namboodiricorresponding author
Link to the study: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2824219/